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The Daily Insight

What causes a cleft lip during pregnancy

Author

Nathan Sanders

Published Apr 05, 2026

Cleft lip and cleft palate are thought to be caused by a combination of genes and other factors, such as things the mother comes in contact with in her environment, or what the mother eats or drinks, or certain medications she uses during pregnancy.

How can I prevent my baby from having a cleft lip?

  1. Take folic acid. …
  2. Don’t smoke or drink alcohol. …
  3. Get a preconception checkup. …
  4. Get to a healthy weight before pregnancy and talk to your provider about gaining a healthy amount of weight during pregnancy.

What foods cause cleft lip?

NEW YORK (Reuters Health) – Pregnant women who eat a meat-rich, fruit-poor diet may be doubling their baby’s likelihood of being born with a cleft lip or cleft palate, Dutch researchers report.

What are the main causes of cleft lip?

  • the genes a child inherits from their parents (although most cases are a one-off)
  • smoking during pregnancy or drinking alcohol during pregnancy.
  • obesity during pregnancy.
  • a lack of folic acid during pregnancy.

Is it my fault my baby has a cleft lip?

What causes cleft lip and palate? These birth defects occur very early in the pregnancy, and we do not know exactly what causes them. However, we know that cleft lip and palate is not caused by anything he mother did or didn’t do during pregnancy. If your child is born with this birth defect, it is not your fault.

Can a cleft lip be seen on ultrasound?

Cleft lip may be detected with ultrasound beginning around the 13th week of pregnancy. As the fetus continues developing, it may be easier to accurately diagnose a cleft lip. Cleft palate that occurs alone is more difficult to see using ultrasound.

Can folic acid prevent cleft lip?

The researchers found that folic acid supplementation of 400 micrograms or more per day reduced the risk of isolated cleft lip with or without cleft palate by one-third, but had no apparent effect on the risk of cleft palate alone.

Does alcohol cause cleft lip?

No significant association was found between alcohol use and isolated cleft palate or clefts in children with multiple birth defects. Alcohol use during pregnancy may be a cause of isolated cleft lip with or without cleft palate.

Can cleft lip be prevented?

While many cases of cleft lip and cleft palate can’t be prevented, consider these steps to increase your understanding or lower your risk: Consider genetic counseling. If you have a family history of cleft lip and cleft palate, tell your doctor before you become pregnant.

Does smoking cause cleft lip?

Maternal smoking is an established risk factor for oral clefts. A recent meta-analysis of 24 studies estimated that mothers who smoked during pregnancy had a 1.3 fold increased risk of having a baby with cleft lip with or without cleft palate, and a 1.2-fold risk of cleft palate alone.

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What vitamin deficiency causes cleft palate?

Deficiency of B vitamins and folic acid in maternal diet is another commonly associated cause of cleft lip and palate in the new born. Parents who are older than usual at the time of birth of their baby are at higher risk of having children with cleft lip and or palate.

Which food has folic acid?

  • Dark green leafy vegetables (turnip greens, spinach, romaine lettuce, asparagus, Brussels sprouts, broccoli)
  • Beans.
  • Peanuts.
  • Sunflower seeds.
  • Fresh fruits, fruit juices.
  • Whole grains.
  • Liver.
  • Seafood.

How is a cleft palate detected?

How is cleft lip/cleft palate diagnosed? In most cases, a prenatal ultrasound can detect cleft lip alone or cleft lip and palate as early as 16 weeks into a pregnancy. The diagnosis is then confirmed at birth with a detailed visual assessment and physical examination.

What syndrome is associated with cleft?

Sometimes when a child is born with a cleft lip and/or palate there is a chance that they may have additional medical condition/s. These associated conditions include ‘Pierre Robin Sequence’ (PRS), Stickler Syndrome and 22q11 Deletion Syndrome.

Can a cleft palate close on its own?

Though the condition is similar to cleft lip, it can exist on its own. Cleft palate repair surgery takes place in an operating room with the infant under general anesthesia. The surgeon makes incisions on both sides of the cleft, then rotates the muscles and tissues, and brings them together to close the cleft.

Can you have a cleft palate without a cleft lip?

Because the lip and the palate develop separately, it is possible to have a cleft lip without a cleft palate, a cleft palate without a cleft lip, or both a cleft lip and cleft palate together (the most frequently occurring defect).

Do prenatal vitamins prevent cleft lip?

For that reason, obstetricians recommend that all pregnant women take a prenatal vitamin with folic acid to prevent these issues, but research has now shown that folic acid could also prevent some oral problems, including cleft palates and lips.

Does folic acid cause cleft palate?

Lack of folic acid early in pregnancy is known to cause neural tube defects such as spina bifida, but this is the first study ever to show a strong association between maternal folic acid intake and the risk of a baby developing cleft lip and cleft palate.

What causes Pierre Robin Syndrome?

In about 20 to 40 percent of cases, the condition occurs alone. The exact causes of Pierre Robin syndrome are unknown. Changes ( mutations ) in the DNA near the SOX9 gene are the most common genetic cause of isolated cases of Pierre Robin sequence.

Can a cleft lip develop after 20 weeks?

The face and upper lip develop during the 5th to 9th weeks of pregnancy. Most cleft problems can either be picked up at the routine 20-week scan or soon after birth. However, a submucous cleft, where the cleft is hidden in the lining of the roof of the mouth, may not be detected for months or even years.

Is cleft palate treated before birth?

Cleft palate can cause serious complications, including difficulty eating and learning to speak. However, close regulation of important signaling molecules during palate formation may one day allow doctors to reverse a cleft palate before the baby is even born, Chai said.

At what age is cleft palate repair?

Most times, cleft palate repair is done when the child is older, between 9 months and 1 year old. This allows the palate to change as the baby grows. Doing the repair when the child is this age will help prevent further speech problems as the child develops.

How much does a cleft lip surgery cost?

Typical costs: Without health insurance, cleft lip and/or palate surgery typically costs $5,000 to $10,000 or more per surgery; if the child has both a cleft lip and a cleft palate, two surgeries typically are required for a total of $10,000 to $20,000.

Can you take folic acid while pregnant?

Folic acid before and during pregnancy It’s important to take a 400 micrograms folic acid tablet every day before you’re pregnant and until you’re 12 weeks pregnant. Folic acid can help prevent birth defects known as neural tube defects, including spina bifida.

What race has the most cleft palate?

Although cleft lip with or without cleft palate can occur in any race, there is a higher incidence in people of Asian, Native American or Hispanic decent. There is a lower incidence in African-American individuals.

Is microcephaly a symptom of fetal alcohol syndrome?

The usual degree of microcephaly in FAS is classified as mild to moderate. It is primarily due to failure of brain growth. The consequences are neither mild nor moderate.

Can a father who smokes cause birth defects?

Paternal smoking is linked to increased risk of congenital heart defects. Summary: Fathers-to-be who smoke may increase the risk of congenital heart defects in their offspring, according to a new study. For mothers-to-be, both smoking and exposure to secondhand smoke were detrimental.

What kind of birth defects can smoking cause?

Smoking raises your baby’s risk for birth defects, including cleft lip, cleft palate, or both. A cleft is an opening in your baby’s lip or in the roof of her mouth (palate). He or she can have trouble eating properly and is likely to need surgery.

Why should you avoid liver when pregnant?

Though it’s full of nutrients, liver contains high levels of a certain type of vitamin A that can potentially cause miscarriage and birth defects in a developing baby, especially during the first couple of months of pregnancy.

When should I take folic acid morning or night?

What is the best time of day to take folic acid? Most nutritionists say to take supplements, like folic acid, in the morning. Digestion slows at night, so taking your vitamins in the morning will allow for better and more efficient absorption into your system.

Which fruit has the most folic acid?

Many fruits contain folic acid, but citrus fruits rank highest – oranges are especially high in the vitamin. Other folate-rich fruits include grapefruits, papayas, grapes, bananas, strawberries, raspberries and cantaloupe.