What is the drug diphenhydramine used for
Lily Fisher
Published Feb 27, 2026
Diphenhydramine is used to relieve red, irritated, itchy, watery eyes; sneezing; and runny nose caused by hay fever, allergies, or the common cold
Is Benadryl and diphenhydramine the same thing?
Benadryl is available in generic forms, which are often store-brand products. The generic name of Benadryl is diphenhydramine.
What happens if you take diphenhydramine every night?
Exposure to diphenhydramine over the short term can make older folks a little squirrely, but long-term use over many years may lead to Alzheimer’s disease. If people are unable to achieve a good night’s sleep, they really need to consult with a physician.
What are the dangers of taking diphenhydramine?
Drowsiness, dizziness, constipation, stomach upset, blurred vision, or dry mouth/nose/throat may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.Is diphenhydramine the same as ibuprofen?
Diphenhydramine is an antihistamine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID).
Is Benadryl good for anxiety?
One of the biggest advantages of using an OTC medication such as Benadryl to treat anxiety is that it is fast-acting and convenient. These qualities can be helpful if you need to reduce symptoms of mild anxiety quickly. Because Benadryl causes many people to feel drowsy, it can also help with sleep.
How many mg of diphenhydramine should I take for sleep?
What is the maximum dose of diphenhydramine for sleep? When used as a sleep aid the maximum recommended dosage is 76mg for diphenhydramine citrate or 50mg for diphenhydramine hydrochloride.
When should you not take diphenhydramine?
Call your doctor if the condition you are treating with diphenhydramine does not improve, or if you have a fever with a headache, cough, or skin rash. Do not use diphenhydramine for longer than 2 weeks to treat sleep problems, or longer than 7 days to treat cold or allergy symptoms.How does diphenhydramine affect the heart?
Diphenhydramine inhibits the potassium channels which can cause QT interval prolongation and abnormal ventricular repolarization, and these changes may be more marked if the patient carries a mutant gene for LQTS.
Does diphenhydramine raise your blood pressure?Official Answer. Increased blood pressure is not a typical side effect of diphenhydramine, a first-generation antihistamine that lowers the effects of histamines in your body. However, in rare cases, the drug may cause hypotension, or decreased blood pressure.
Article first time published onHow effective is diphenhydramine for sleep?
While antihistamines may help you to fall asleep, overall sleep quality is usually not very good, he said. Sometimes, they even have the opposite affect and cause hyperactivity, especially in children. “Using Benadryl or any antihistamine for sleep has no long term benefit,” Alapat said.
What is the safest sleeping pill for the elderly?
In the elderly, nonbenzodiazepines such as zolpidem, eszopiclone, zaleplon, and ramelteon are safer and better tolerated than tricyclic antidepressants, antihistamines, and benzodiazepines. Pharmacotherapy should be recommended only after sleep hygiene is addressed, however.
Is diphenhydramine habit forming?
Indeed, case reports and surveys have linked diphenhydramine to recreational abuse and dependence. And a 2008 study on rats found that diphenhydramine might be habit-forming: The study concludes that the drug enhanced the release of dopamine in the brain—resulting in a sensation similar to that produced by cocaine.
Can you take diphenhydramine with Tylenol?
No interactions were found between diphenhydramine and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
Is diphenhydramine an anti inflammatory?
DIPHENHYDRAMINE; IBUPROFEN (dye fen HYE dra meen; eye BYOO proe fen) is a combination of a sleep-aid and a non-steroidal anti-inflammatory drug (NSAID). It is used to treat occasional sleeplessness with minor aches and pains.
Can you mix Benadryl and Tylenol?
No interactions were found between Benadryl and Tylenol. This does not necessarily mean no interactions exist. Always consult your healthcare provider.
What is the 3 3 3 rule for anxiety?
Follow the 3-3-3 rule. Look around you and name three things you see. Then, name three sounds you hear. Finally, move three parts of your body — your ankle, fingers, or arm.
What is a drug that calms you down?
Benzodiazepines most commonly used to treat anxiety disorders are clonazepam (Rivotril)*, alprazolam (Xanax) and lorazepam (Ativan). Also used are bromazepam (Lectopam), oxazepam (Serax), chlordiazepoxide (once marketed as Librium), clorazepate (Tranxene) and diazepam (Valium).
Does Benadryl help with depression?
Benadryl and depression: Is there a link? There are no studies linking Benadryl, or its active ingredient diphenhydramine, directly to the symptoms of clinical depression. Feeling tired, lethargic, or mentally foggy on Benadryl is often from the drug’s CNS depressant effects.
Can diphenhydramine cause heart palpitations?
A fast heartbeat is a common side effect of Benadryl. In rare cases, it can become serious. Symptoms of a fast heartbeat may include: feeling like your heart is racing.
What is another name for diphenhydramine?
BRAND NAME(S): Benadryl, Genahist, Sominex, Unisom. USES: Diphenhydramine is an antihistamine used to relieve symptoms of allergy, hay fever, and the common cold. These symptoms include rash, itching, watery eyes, itchy eyes/nose/throat, cough, runny nose, and sneezing.
What does diphenhydramine do to the brain?
Human research to suggest diphenhydramine impairs cognitive function: Many acute or short-term double-blind randomized controlled trials have shown that diphenhydramine impairs cognitive functions such as alertness [5], attention [6], aversive memory [7], working memory [6; 8], executive function [9], reaction time [8] …
Is diphenhydramine a depressant?
Diphenhydramine may increase the central nervous system depressant (CNS depressant) activities of Anisotropine methylbromide. The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Antazoline. The metabolism of Antipyrine can be decreased when combined with Diphenhydramine.
Which antihistamine is best for sleep?
Diphenhydramine is a sedating antihistamine. Side effects might include daytime drowsiness, dry mouth, blurred vision, constipation and urinary retention. Doxylamine succinate (Unisom SleepTabs). Doxylamine is also a sedating antihistamine.
Are antihistamines bad for your heart?
“In general, antihistamines are safe in patients with high blood pressure and other forms of heart disease,” explains Richard Krasuski, MD, director of adult congenital heart disease services at the Cleveland Clinic in Ohio, but an antihistamine may elevate blood pressure or increase heart rate, according to the U.S. …
How much sleep does a 70 year old woman need?
Most healthy older adults age 65 or older need 7-8 hours of sleep each night to feel rested and alert.
What helps seniors sleep better?
- Take a warm bath. When you get out of the tub, the drop in body temperature may help you feel tired. …
- Take time to calm down before you turn out the lights. …
- Make the bedroom a sleep zone. …
- Avoid afternoon naps. …
- Don’t drink alcohol close to bedtime. …
- Drink less fluids at night.
What will a psychiatrist prescribe for insomnia?
Instead, modern psychiatrists tend to prescribe benzodiazepines such as diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), and clonazepam (Klonopin) for insomnia, especially in patients with mood or anxiety disorders (Lader M, Addiction 2011;89(11):15351541).
How can I stay asleep all night?
- Establish a quiet, relaxing bedtime routine. …
- Relax your body. …
- Make your bedroom conducive to sleep. …
- Put clocks in your bedroom out of sight. …
- Avoid caffeine after noon, and limit alcohol to 1 drink several hours before bedtime. …
- Avoid smoking. …
- Get regular exercise. …
- Go to bed only when you’re sleepy.
How can I sleep without sleeping pills?
- Stick to a regular sleep schedule (same bedtime and wake-up time), seven days a week.
- Exercise at least 30 minutes per day most days of the week. …
- Get plenty of natural light exposure during the day. …
- Establish a regular, relaxing bedtime routine.
- Take a warm bath or shower before bed.
Is diphenhydramine bad for your liver?
Despite widespread use over many decades, diphenhydramine has not been linked to liver test abnormalities or to clinically apparent liver injury. The reason for its safety may relate its short half-life and limited duration of use.